Study of the Effect of Regional Nerve Blocks on Pain and Inflammation After Video Assisted Thorascopic Lung Surgery

Stopped early · Not applicable · Has a placebo group

Conditions studied: Pain

In brief

The purpose of this study is to compare: 1. The degree of systemic postoperative inflammation (cytokine measurement) with the degree of post-operative pain 2. The degree of pain and nausea and 3. The pre and post operative pulmonary functions following Video Assisted Thorascopic Surgery (VATS) performed under general anesthesia with the addition of intra-operative single-injection paravertebral blockade vs general anesthesia with a sham intra-operative paravertebral nerve blockade

Key facts

Study ID

NCT00639795

Run by

Memorial Medical Center

People needed

60

Starts

2008-03-01

Expected to finish

2011-03-01

Last updated by the study team

2013-07-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than 18
• Planned thoracoscopy with low probability(by surgeon estimate) of conversion to open procedure

You may not qualify if…

• Age less than 18
• Clinical or laboratory evidence of systemic infection
• Current pregnancy as assessed by preoperative urine HCG test
• Serious, uncontrolled, non-malignant illness
• Malignant illness requiring systemic chemotherapy in the last 6 months
• Documented allergy to oxycodone, morphine sulfate or acetaminophen
• Contraindication to peripheral nerve blockade or general anesthesia including:
• patient refusal
• active infection at site of planned block
• documented allergy to any local or general anesthetic medications
• significant coagulopathy( prothrombin time >15 seconds, INR>1.5
• pre-existing neuropathy and medical conditions or deformities which would compromise block or anesthetic safety
• Planned pleurodesis
• Current use of high dose inhaled or systemic steroids
• Current use of Amiodarone (Cordarone)
• Morbid obesity (BMI=40kg/m2)
• Patients with clinically significant mental health issues such as psychosis requiring treatment with antipsychotic medications.
• Patients unable to consent
• Patients with active infections requiring antibiotics within one month of registration
• Participation in other clinical trials that may interfere with this study

Where it is running

• Memorial Medical Center — Johnstown, Pennsylvania, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.