Memory and the Hippocampus in Twins
Completed
Conditions studied: PTSD, Stress Disorders, Post-Traumatic
In brief
The purpose of this project is to measure brain markers and cognitive factors in twins with a history of military service with and without PTSD, and to follow them over time and measure changes in brain function and cognitive variables.
Key facts
- Study ID
- NCT00638885
- Run by
- US Department of Veterans Affairs
- People needed
- 142
- Starts
- 2010-04-01
- Expected to finish
- 2013-06-01
- Last updated by the study team
- 2015-01-15
Who can join
Age: 50 and older, up to 70. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- All twins will be required to give written informed consent.
- Subjects will be included with a history of Vietnam Era service.
- All subjects must be free of major medical illness on the basis of history and physical examination, lab testing, and electrocardiogram.
You may not qualify if…
- Subjects will be excluded with a history of shrapnel or other foreign bodies that would preclude MRI scanning, history of loss of consciousness, or neuroleptics, sedative or benzodiazepine medication usage within the previous four weeks.
- Subjects will also be excluded if based on the SCID interview they have comorbid:
- schizophrenia;
- schizoaffective disorder;
- bulimia or anorexia, or
- bipolar disorder.
- Subjects will also be excluded with a history of blast injury with associated traumatic brain injury.
- In addition, subjects will be excluded with a history of alcohol or substance abuse/dependence within the past year. We will use the strategy used in prior MRI studies and use multivariate analyses to examine the contribution of past histories of alcohol and substance abuse (as measured with the Addiction Severity Index) and depression symptom level (as measured with the Hamilton Depression Scale) to the outcomes of interest.
- Subjects will be excluded from the study if they present with a history of serious medical or neurological illness, or as a result of routine laboratory studies, history of asthma, steroid usage, seizure disorder, or prenatal/perinatal substance exposure or trauma.
Where it is running
- Atlanta VA Medical and Rehab Center, Decatur — Decatur, Georgia, United States
Full record on ClinicalTrials.gov
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