Carvedilol and Micro T-Wave Alternans in Hypertensives With Chronic Kidney Disease

Stopped early · Not applicable · Has a placebo group

Conditions studied: Vascular Disease, Kidney Disease

In brief

Evaluate effectiveness of Carvedilol CR on Micro T-Wave Alternans in high risk hypertensives

Key facts

Study ID

NCT00638222

Run by

University of Toledo Health Science Campus

People needed

6

Starts

2008-05-01

Expected to finish

2010-12-01

Last updated by the study team

2014-11-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults age 18 and older
• Chronic kidney disease
• Must be able to do stress test

You may not qualify if…

• Must not be mentally disabled
• Unable to provide informed consent
• Unable or unwilling to comply with study protocol or procedures
• Pregnancy or unknown pregnancy status in female of childbearing potential
• Participation in any drug trial during the study period
• Prior enrollment in this study
• Active liver disease
• Currently on β-blocker medication at the time of enrollment
• Known history of asthma exacerbation with β-blocker therapy
• Second or third degree AV nodal block or bradycardia with resting heart rate <50 bpm
• Prior allograft organ transplantation
• Planned allograft transplantation reasonably foreseen within the active treatment period
• Electrocardiographic left or right bundle branch block
• Permanent implanted pacemaker
• Atrial fibrillation
• Ongoing treatment with any of the following medications: sotalol (Betapace), azimilide (Stedicor), quinidine (Quinidex), disopyramide (Norpace), dofetilide (Tikosyn), ibutilide (Corvert), procainamide (Procanbid), bepridil (Vascor), amiodarone (Cordarone), clarithromycin (Biaxin), erythromycin (Eryc), halofantrine (Halfan), pentamidine (Pentam), sparfloxacin (Zagam), domperidone (Motilium), droperidol (Inapsine), chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), thioridazine (Mellaril), pimozide (Orap), arsenic trioxide (Trisenox), cisapride (Propulsid), lidoflazine (Clinium), and methadone (Dolophine)

Where it is running

• University of Toledo, Health Science Campus — Toledo, Ohio, United States
• Site Rhode Island Hospital — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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