Surgical Versus Nonoperative Treatment of Metastatic Epidural Spinal Cord Compression

Completed

Conditions studied: Metastatic Epidural Spinal Cord Compression

In brief

The aim of this trial is to evaluate the differences in pain relief, neurological function, quality of life and survival in patients with metastatic epidural spinal cord compression (MESCC) who are managed with a combination of surgery and radiotherapy versus radiotherapy alone. Further we shall evaluate cost-effectiveness of the two treatment approaches.

Key facts

Study ID

NCT00634426

Run by

AOSpine North America Research Network

People needed

163

Starts

2008-03-01

Expected to finish

2013-03-01

Last updated by the study team

2015-05-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Single symptomatic metastatic epidural spinal compression at any level confirmed by MRI
• Age 18 and more
• Able and willing to give written informed consent to participate in the study
• Able to read and write English on an elementary level

You may not qualify if…

• Multiple symptomatic spinal metastases
• Radiosensitive tumors
• Radioresistant tumors
• Primary cancer site in CNS or spine
• Poor life expectancy (< 3 months)
• Patients with a tumor that has compressed only the cauda equina or spinal roots
• Has a recent history of substance abuse
• Is a prisoner
• Currently involved in another study
• has a disease or condition that would preclude accurate evaluation

Where it is running

• University of Kansas Medical Center — Kansas City, Kansas, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Thomas Jefferson University and The Rothman Institute — Philadelphia, Pennsylvania, United States
• University of Texas Hospital / MD Anderson Cancer Center — Houston, Texas, United States
• West Viginia University — Morgantown, West Virginia, United States
• University of British Columbia — Vancouver, British Columbia, Canada
• Sunnybrook Health Sciences Center — Toronto, Ontario, Canada
• University of Toronto — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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