Effect of Celecoxib Versus Placebo Before and After Knee Surgery on the Overall Use of Analgesics After Surgery

Completed · Phase 4 · Has a placebo group

Conditions studied: Arthroscopy

In brief

To compare the total analgesic use at 24 hours after arthroscopic knee surgery in patients treated with celecoxib versus placebo.

Key facts

Study ID

NCT00633386

Run by

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

People needed

200

Starts

2003-02-01

Expected to finish

2003-08-01

Last updated by the study team

2021-02-21

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed knee meniscus pathology requiring ambulatory arthroscopic meniscectomy or partial meniscectomy
• Willing to participate in study for 36 hours and come to follow-up visit 7 days post-surgery

You may not qualify if…

• Osteoarthritis, inflammatory arthritis, or previous fracture of index joint
• Received acetaminophen or low-dose narcotic within 8 hours of surgery
• Have received oral (4 weeks), intramuscular (2 months), intra-articular (3 months) or soft-tissue (2 months) injections of corticosteroids of the first dose of study medication or received intra-articular injections of hyaluronic acid in the index joint within 9 months of the first dose of study medication

Where it is running

• Pfizer Investigational Site — Phoenix, Arizona, United States
• Pfizer Investigational Site — St. Petersburg, Florida, United States
• Pfizer Investigational Site — Baltimore, Maryland, United States
• Pfizer Investigational Site — Springfield, Massachusetts, United States
• Pfizer Investigational Site — Springfield, Missouri, United States
• Pfizer Investigational Site — Columbia, South Carolina, United States
• Pfizer Investigational Site — Johnson City, Tennessee, United States
• Pfizer Investigational Site — San Antonio, Texas, United States
• Pfizer Investigational Site — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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