Identification and Treatment of Clinically Silent Catheter-Related Deep Vein Thrombosis in Children With Cancer
Stopped early · Phase 2
Conditions studied: Childhood Cancer, Central Venous Catheters, Deep Vein Thrombosis, Catheter-related Infection, Catheter-related Occlusion
In brief
The primary hypothesis of this study is that occult catheter-related DVT in children with cancer is common and directly contributes to development of serious catheter complications, specifically bacteremia/fungemia and/or recurrent occlusion of the catheter tip. Accordingly, anticoagulant treatment of clinically silent (occult) DVT will reduce rates of catheter-related infection and occlusion, delays in therapy and need for catheter replacement.
Key facts
- Study ID
- NCT00633061
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 136
- Starts
- 2008-06-01
- Expected to finish
- 2011-12-01
- Last updated by the study team
- 2020-10-08
Who can join
Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of cancer
- Age ≤ 18 years
- First tunneled central venous catheter (implanted port or external) inserted in the upper venous system (subclavian, brachiocephalic, or jugular vein) within the previous 2 weeks
- Catheter expected to be in place for duration of chemotherapy (≥ 3 months)
- History of no more than one catheter complication (occlusion or infection)
You may not qualify if…
- Prior history of DVT
- Currently receiving an anticoagulant or anti-platelet agents on a daily basis
- Diagnosis of high grade malignant brain tumor or metastasis to the brain
- Clinical signs/symptoms of DVT
- Clinical signs/symptoms of Pulmonary embolism
- Renal failure
- Recent major hemorrhage
Where it is running
- Children's Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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