Virtual Reality & D-cycloserine (DCS) for Posttraumatic Stress Disorder (PTSD)
Completed · Not applicable · Has a placebo group
Conditions studied: Posttraumatic Stress Disorder
In brief
This study proposes to evaluate the effects of D-cycloserine (DCS) combined with Virtual Reality exposure therapy in a sample of patients who developed posttraumatic stress disorder (PTSD) following either the events of September 11, 2001, or military service in the war in Iraq. In addition, this study hopes to determine whether a common human genetic single nucleotide polymorphism (SNP) in a growth factor, brain derived neurotrophic factor, BDNF (Val66Met), predicts treatment response to PTSD. Overall, this study aims 1) to determine if subjects administered DCS show a significantly larger decrease in symptoms of PTSD as compared to those administered a placebo, 2) to determine if subjects administered DCS show a decrease in PTSD symptomatology significantly earlier (as measured by weeks) than those administered a placebo, 3) to determine if differences in symptomatology are evident at a 6-month follow-up and indicate long-term differences between groups, and 4) to determine if the BDNF SNP predicts treatment response.
Key facts
- Study ID
- NCT00632632
- Run by
- Weill Medical College of Cornell University
- People needed
- 25
- Starts
- 2005-01-01
- Expected to finish
- 2012-12-01
- Last updated by the study team
- 2015-08-27
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- English-speaking adults
- Between the ages of 18 and 70
- Exposed to the WTC Attacks (were in towers or in the immediate area) or veterans of the Iraq War
- Diagnosed with PTSD symptoms.
You may not qualify if…
- Presence of current organic mental disorder
- Schizophrenia
- Bipolar disorder
- Depression with psychotic features
- Current substance dependence
- Delusional disorder
- Active suicidal ideation, intent, or plan
- Active homicidal ideation, intent, or plan
- Use of pacemaker
- Medically unstable
- Pregnant or lactating
- A history of severe renal disease
- History of seizures
- Currently taking anticoagulants, ethionamide (Trecator-SC) or isoniazid (INH)
- History of allergic reaction to cycloserine.
Where it is running
- Weill Cornell Medical College — New York, New York, United States
Full record on ClinicalTrials.gov
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