Evaluating the Effects of Supplemental Vitamin C on Infant Lung Function in Pregnant Smoking Women

Completed · Not applicable · Has a placebo group

Conditions studied: Pregnancy, Smoking

In brief

Women who smoke during their pregnancy place their unborn child at an increased risk of health problems, including decreased lung function and possible lung diseases later in life. Preliminary animal research suggests that if vitamin C is taken during pregnancy, nicotine's harmful effects on the unborn baby's developing lungs may be blocked. This study will determine the effect that vitamin C has on the lung development and function of babies born to women who smoke during pregnancy.

Key facts

Study ID

NCT00632476

Run by

Oregon Health and Science University

People needed

282

Starts

2007-03-01

Expected to finish

2012-07-01

Last updated by the study team

2013-09-04

Who can join

Age: 15 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Randomly assigned to a study intervention at less than 22 weeks of gestation
• History of smoking
• Singleton gestation pregnancy
• Smoking cessation intervention offered but declined

You may not qualify if…

• Multiple gestation pregnancy
• Documented major fetal congenital anomalies
• History of kidney stones
• Insulin dependent diabetes
• Current participation in other research projects that may interfere with this study
• Continuous use of high dose vitamin C since last menstrual period (LMP) or initial ascorbic acid level greater than 100 micromoles/liter

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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