Intraoperative Optical Imaging of Brain Function

Withdrawn before enrolling

Conditions studied: Brain Tumor

In brief

The goal of this proposal is to test the performance of a novel optical imaging system for real-time quantitative imaging of brain function through multiple hemodynamic measures during neurosurgery. This pilot study encompasses two sub-aims: * Evaluate the ability of laser speckle contrast imaging to image cerebral blood flow (CBF) intraoperatively. We will image the changes in CBF in response to somatosensory stimulation. (5 patients). * Simultaneously image hemoglobin oxygenation, blood volume, blood flow, and cerebral metabolic rate of oxygen (CMRO2) changes during somatosensory stimulation using a combined laser speckle and multi-wavelength reflectance imaging system. (5 patients).

Key facts

Study ID

NCT00632437

Run by

M.D. Anderson Cancer Center

People needed

0

Starts

2008-02-01

Expected to finish

2010-06-01

Last updated by the study team

2012-07-30

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Location of planned resection near somatosensory cortex.
• Planned intraoperative electrocortical mapping.
• Able to render written informed consent.

You may not qualify if…

• Patients with a hemiparesis graded 3/5 (active movement against gravity) or worse. Unpublished data from MDACC Department of Neurosurgery suggests that cortical mapping is ineffective in these patients because an adequate cortical response is not detected
• Patients with a vascular malformation within the proximity of the cortex area imaged.

Where it is running

• U.T.M.D. Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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