Assessment of Hemodynamic Changes During Weaning From Mechanical Ventilation With Flo-Trac Vigileo (TM) Monitor.
Withdrawn before enrolling
Conditions studied: Mechanical Ventilation
In brief
Failure to wean from mechanical ventilation (failure to get the patients off the breathing machine) is associated with prolonged stay in the intensive care unit and increased risk of death. Some patients have difficulty successfully getting off the ventilator and breathing on their own. Usually this difficulty is due to lung problems. But sometimes it is due to heart problems, or heart failure. To improve a patient's chances of successfully getting off the ventilator early, it is helpful to the doctors to know if patient has heart failure and to measure how severe. With the new monitoring system being studied here, doctors may be able to detect and measure heart failure more easily. A new monitor (Vigileo TM) that is connected with a specific cable (Flo-TracTM) to a catheter that is inside the patient's artery (arterial line) has lately been developed. This monitor can estimate the amount of blood that the heart is pumping per minute, known as cardiac output. The heart is supposed to pump blood harder when a patient is being weaned from the breathing machine. With the above mentioned monitor, we hope to detect those patients whose hearts are weak and are not pumping as hard as they should.
Key facts
- Study ID
- NCT00631683
- Run by
- The University of Texas Health Science Center, Houston
- People needed
- 0
- Starts
- 2008-02-01
- Expected to finish
- 2008-02-01
- Last updated by the study team
- 2020-11-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years or older
- Arterial line in place
- Normal sinus rhythm by electrocardiographic monitoring
- Mechanical ventilation for at least 24 hours
- Ventilation via oral or nasal endotracheal tube
- Patient meets the following weaning criteria before starting weaning protocol:
- PaO2/FiO2 ratio >200
- FiO2 equal or less than 50%
- Positive end-expiratory pressure (PEEP) 5cm H20 or less
- Respiratory frequency/Tidal volume ratio less 105
- Respiratory rate < 30 breaths/min
- Presence of cough and gag reflex
- 12 hours free from sedation (opioids/benzodiazepine)
- 2 hours free from sedation in case patient is on Propofol
- Systolic blood pressure above 90 mmHg and below 180 mmHg
- Heart rate below 130 beats/min
You may not qualify if…
- Known neurological disorder that might impair ventilatory drive
- Known neuromuscular disease
- Inotropic or vasopressor infusion
- Cardiac pacemaker
- Terminal condition
Where it is running
- Memorial Hermann Hospital — Houston, Texas, United States
Full record on ClinicalTrials.gov
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