Transthyretin Amyloidosis Outcome Survey (THAOS)

Completed

Conditions studied: Transthyretin Gene Mutations, Transthyretin Amyloidosis

In brief

THAOS is a global, multi-center, longitudinal observational survey open to all patients with transthyretin amyloidosis (ATTR), including ATTR-PN (polyneuropathy), ATTR-CM (cardiomyopathy) and wild-type ATTR-CM. It is open-ended with a minimum duration of 10 years. Patients will be followed as long as they are able to participate. The principal aims of this outcome survey are to better understand and characterize the natural history of the disease by studying a large and heterogenous patient population. Survey data may be used to develop new treatment guidelines and recommendations, and to inform and educate clinicians about the management of this disease.

Key facts

Study ID

NCT00628745

Run by

Pfizer

People needed

6718

Starts

2008-01-04

Expected to finish

2023-06-19

Last updated by the study team

2024-11-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Patients meeting any of the following will not be included in the study:
• Patient has evidence of primary (light chain) or secondary amyloidosis.

Where it is running

• Mayo Clinic Arizona — Phoenix, Arizona, United States
• VA Greater Los Angeles Healthcare System — Los Angeles, California, United States
• University of California, Irvine — Orange, California, United States
• University of California - San Francisco, UCSF Department of Neurology — San Francisco, California, United States
• Office of Sponsored Research — San Francisco, California, United States
• Stanford University School of Medicine — Stanford, California, United States
• UC Denver — Aurora, Colorado, United States
• Smilow Cancer Hospital at Yale-New Haven — New Haven, Connecticut, United States
• UHealth Deerfield Beach — Deerfield Beach, Florida, United States
• University of Miami Hospital & Clinics — Miami, Florida, United States
• UHealth Plantation — Plantation, Florida, United States
• Clinical Trials Unit — Chicago, Illinois, United States
• Northwestern University — Chicago, Illinois, United States
• University of Chicago Medical Center IRB — Chicago, Illinois, United States
• University of Chicago Medical Center — Chicago, Illinois, United States
• Advocate Christ Medical Centre — Oak Lawn, Illinois, United States
• John Ochsner Heart & Vascular Institute — New Orleans, Louisiana, United States
• University of Maryland School of Medicine — Baltimore, Maryland, United States
• University of Maryland — Baltimore, Maryland, United States
• Johns Hopkins Hospital — Baltimore, Maryland, United States
• Harvard Vanguard Medical Associates — Boston, Massachusetts, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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