Effects of Sternal Wall Pressure in Children

Completed

Conditions studied: Respiration, Artificial

In brief

This protocol is a prospective, pilot, observational study in the Pediatric Intensive Care Unit (PICU), Progressive Care Unit (PCU) and the Operating Room (OR) settings at the Children's Hospital of Philadelphia (CHOP). We propose to observe, measure and report the effect of incremental gentle sternal pressure increases on intrathoracic pressure, and other surrogates of hemodynamic function, in stable mechanically ventilated children. This study will provide preliminary data to inform the resuscitation research community and assist development of evidence-based pediatric resuscitation guidelines in the future.

Key facts

Study ID

NCT00628407

Run by

Children's Hospital of Philadelphia

People needed

13

Starts

2007-01-01

Expected to finish

2009-12-01

Last updated by the study team

2011-03-11

Who can join

Age: 1 and older, up to 7. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 6 months to < 8 years.
• Weight greater than 4.8 kg.
• Hemodynamically stable (defined by the Pediatric Critical Care Team, Anesthesiologists and Surgeons)
• Volume Limited Ventilation Mode on Conventional Mechanical Ventilator
• Vascular catheters in place (for at least 10 subjects)
• Parental/guardian permission (informed consent) and if appropriate, child assent.

You may not qualify if…

• Patients with contraindication to gentle, direct chest wall pressure (e.g. fresh sternotomy, recent chest wall surgery, chest tube in place)

Where it is running

• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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