Study of CE-224,535 A Twice Daily Pill To Control Rheumatoid Arthritis In Patients Who Have Not Totally Improved With Methotrexate

Completed · Phase 2 · Has a placebo group

Conditions studied: Arthritis, Rheumatoid

In brief

CE-224,535 is known to block a chemical that acts as a gateway to some of your immune cells. Blocking this gateway prevents the cells from pushing out 2 chemicals called IL-1 and IL-18 that are known to cause some of the inflammation seen in rheumatoid arthritis. It is hoped that taking this drug will reduce the symptoms of rheumatoid arthritis

Key facts

Study ID

NCT00628095

Run by

Pfizer

People needed

100

Starts

2008-04-07

Expected to finish

2009-02-04

Last updated by the study team

2022-04-04

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Active rheumatoid arthritis
• Incomplete response to methotrexate

You may not qualify if…

• Must not be on biologic therapies
• No recent infections

Where it is running

• Arizona Arthritis & Rheumatology Associates, P.C. — Mesa, Arizona, United States
• Omega Research Consultants LLC — DeBary, Florida, United States
• Florida Arthritis Center — Lake Mary, Florida, United States
• Tampa Medical Group, PA — Tampa, Florida, United States
• American Health Network — Avon, Indiana, United States
• Best Clinical Trials, LLC (Administrative Only) — New Orleans, Louisiana, United States
• George Stanley Walker, MD — New Orleans, Louisiana, United States
• Majid Abdul Jawad, MD — New Orleans, Louisiana, United States
• The Arthritis and Osteoporosis Center of Maryland — Frederick, Maryland, United States
• University Physicians — Columbia, Missouri, United States
• University of Missouri-Columbia — Columbia, Missouri, United States
• Arthritis Center of Reno — Reno, Nevada, United States
• New Horizons Clinical Research — Cincinnati, Ohio, United States
• Arthritis Northwest — Spokane, Washington, United States
• Clínica Santa María, Sección Reumatología — Providencia, Santiago, RM, Chile
• Revmatologicka ambulance — Česká Lípa, Czechia
• Revmatologicky ustav — Prague, Czechia
• Revmatologicka ambulance — Prague, Czechia
• Investigadores Clinicos Asociados — México, D.F., Mexico
• Krakowskie Centrum Medyczne NZOZ — Krakow, Poland
• Zaklad Reumatologii i Immunologii Klinicznej — Poznan, Poland
• Oddzial Reumatologiczno-Rehabilitacyjny IIR Ortopedyczno-Rehabilitacyjny — Poznan, Poland
• Inha University Hospital, Medicine/Rheumatology — Incheon, South Korea
• Pusan National University Hospital, Rheumatology, Internal Medicine — Pusan, South Korea
• Hospital Nuestra Señora de La Esperanza — Santiago de Compostela, A Coruña, Spain

Full record on ClinicalTrials.gov

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