The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function

Completed

Conditions studied: Cardiovascular Disease

In brief

Our main hypothesis is that EPC function is impaired in some populations with high cardiovascular risk as a result of reduced eNOS-dependent NO production.

Key facts

Study ID

NCT00627068

Run by

University of California, San Francisco

People needed

60

Starts

2007-07-01

Expected to finish

2010-12-01

Last updated by the study team

2011-09-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Willing and able to give written informed consent and comply with study requirements
• Adult of 18 years or older
• Subjects willing to provide blood and tissue samples

You may not qualify if…

• Failure to give informed consent.
• Those unable to consent for themselves.
• Those who cannot read English.
• Patients on Viagra, Levitra, or Cialis
• Patients with malignant disease
• Patients with hematological abnormalities
• Patients with fevers of unknown origin
• Severe comorbidity or alcohol/drug dependence
• Women who are post-menopausal and on hormone replacement therapy, or premenopausal and on birth control pills (premenopausal women will be screened verbally and then by assay of LH and FSH levels in blood samples to identify women in the follicular phase of their menstrual cycle, to reduce variability)

Where it is running

• UCSF, Department of Cardiology — San Francisco, California, United States

Full record on ClinicalTrials.gov

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