Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)
Running, not enrolling · Phase 3
Conditions studied: Brain and Central Nervous System Tumors
In brief
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may kill more tumor cells. It is not yet known whether giving temozolomide during and/or after radiation therapy is more effective than radiation therapy alone in treating anaplastic glioma. PURPOSE: This randomized phase III trial is studying giving temozolomide during and/or after radiation therapy to see how well it works compared to radiation therapy alone in treating patients with anaplastic glioma.
Key facts
- Study ID
- NCT00626990
- Run by
- European Organisation for Research and Treatment of Cancer - EORTC
- People needed
- 751
- Starts
- 2007-12-01
- Expected to finish
- 2029-12-01
- Last updated by the study team
- 2023-09-11
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States
- UCSF University of California San Francisco Medical Center-Mount Zion — San Francisco, California, United States
- University of Florida — Gainesville, Florida, United States
- Mayo Clinic in Florida — Jacksonville, Florida, United States
- Florida Hospital — Orlando, Florida, United States
- Emory University — Atlanta, Georgia, United States
- Memorial Health University Medical Center — Savannah, Georgia, United States
- Northwestern University — Chicago, Illinois, United States
- Loyola University Medical Center — Maywood, Illinois, United States
- Oncology Associates PC — Fort Wayne, Indiana, United States
- Parkview Hospital — Fort Wayne, Indiana, United States
- Saint Vincent Oncology Center — Indianapolis, Indiana, United States
- McFarland Clinic — Ames, Iowa, United States
- June E. Nylen Cancer Center — Sioux City, Iowa, United States
- Via Christi Regional Medical Center — Wichita, Kansas, United States
- Wesley Medical Center — Wichita, Kansas, United States
- Maine Medical Center — Scarborough, Maine, United States
- Boston Medical Center — Boston, Massachusetts, United States
- Brigham and Women's Hospital — Boston, Massachusetts, United States
- Massachussets General Hospital Cancer Center — Boston, Massachusetts, United States
- Saint Joseph Mercy Hospital — Ann Arbor, Michigan, United States
- Henry Ford Hospital — Detroit, Michigan, United States
- West Michigan Cancer Center — Kalamazoo, Michigan, United States
- St John's Mercy Medical Center — St Louis, Missouri, United States
- Arizona Oncology Services Foundation — Phoenix, Arizona, United States
Full record on ClinicalTrials.gov
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