Multicenter ACL Revision Study (MARS)

Running, not enrolling

Conditions studied: Rupture of Anterior Cruciate Ligament

In brief

The purpose of this study is to determine the effects of modifiable risk factors on patient-reported quality of life, physical activity levels, and risk of early osteoarthritis following revision anterior cruciate ligament (ACL) reconstruction. The investigators hypothesize that modifiable variables exist at the time of revision ACL reconstruction (e.g., cause of failure, current graft source and type, surgical exposure, and femoral and tibial tunnel position) which will be predictors of patient-reported outcomes.

Key facts

Study ID

NCT00625885

Run by

Vanderbilt University

People needed

1234

Starts

2006-03-26

Expected to finish

2029-08-31

Last updated by the study team

2025-06-17

Who can join

Age: 12 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All ACL-deficient candidates presenting to the clinic, between the ages of 12† and 65, scheduled to have a revision ACL reconstruction by a participating (MARS Study) surgeon.
• All participants must have undergone a primary ACL reconstruction in the past and are currently identified as having experienced failure of their primary ACL reconstruction, as defined by either MRI, knee laxity (KT > 5mm), a positive pivot shift or Lachman's, functional instability, and/or by arthroscopic confirmation.
• All ACL-deficient patients seeking a revision ACL reconstruction that have either partial (Grade I or II) and/or complete (Grade III) simultaneous ligamentous injuries to the collateral ligaments (MCL or LCL) and/or the posterior cruciate ligament (PCL) will also be included.
• Non-operative treatment of patients with ACLR failure are also eligible to participate.
• The following graft types will be the only ones accepted for inclusion:
• any autograft
• Fresh-frozen allografts from a single donor source (Musculoskeletal Transplant Foundation (MTF); Edison, NJ). These grafts should consist of either:
• bone-patellar tendon-bone
• tibialis anterior/posterior
• achilles tendon

You may not qualify if…

• Patients presenting with prior infection, arthrofibrosis, or regional pain syndrome.
• Subjects will be excluded if their allograft source does not come from MTF.
• Patients unwilling or unable to complete their repeat questionnaire two years after their initial visit.

Where it is running

• Scripps Memorial Hospital (OrthoCal Healthcare) — La Jolla, California, United States
• University of California - Los Angeles (UCLA) — Los Angeles, California, United States
• University of California - San Francisco — San Francisco, California, United States
• Orthopaedic Associates of Aspen and Glenwood — Aspen, Colorado, United States
• University of Colorado — Boulder, Colorado, United States
• Connecticut Children's Medical Center — Farmington, Connecticut, United States
• University of Connecticut Health Center — Farmington, Connecticut, United States
• UHZ Sports Medicine Institute — Coral Gables, Florida, United States
• Intermountain Orthopaedics — Boise, Idaho, United States
• Rush University Medical Center — Chicago, Illinois, United States
• Methodist Sports Medicine Center — Indianapolis, Indiana, United States
• University of Iowa — Iowa City, Iowa, United States
• Cheaspeake Orthopaedics and Sports Medicine Center — Glen Burnie, Maryland, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Regions Hospital (Health Partners Research Foundation) — Saint Paul, Minnesota, United States
• Washington University at St. Louis — St Louis, Missouri, United States
• Bridger Orthopaedic and Sports Medicine — Bozeman, Montana, United States
• New Hamphsire Knee Center — Holderness, New Hampshire, United States
• Robert Wood Johnson Medical School — New Brunswick, New Jersey, United States
• Princeton Orthopaedic Associates — Princeton, New Jersey, United States
• University of Buffalo — Buffalo, New York, United States
• NYU School of Medicine — New York, New York, United States
• Hospital for Special Surgery — New York, New York, United States

Full record on ClinicalTrials.gov

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