Research Study To Test Carvedilol CR + Lisinopril Versus Lisinopril + Placebo In Patients With High Blood Pressure

Completed · Phase 3 · Has a placebo group

Conditions studied: Hypertension

In brief

Randomized, double-blind, parallel group, multicenter study of subjects with Stage 1 or 2 essential hypertension who are not at target blood pressure (\<140/90mmHg) at Baseline. Subjects will be randomized to receive either carvedilol CR + lisinopril or lisinopril + placebo. Subjects will be uptitrated over a 6 week period until target blood pressure (\<140/90mmHg) is met. The primary objective of the study is to compare the proportion of subjects who achieve target blood pressure after 6 weeks of treatment.

Key facts

Study ID

NCT00624065

Run by

GlaxoSmithKline

People needed

348

Starts

2008-03-01

Expected to finish

2008-08-01

Last updated by the study team

2016-12-28

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female age 18-80 years; stage 1 or 2 hypertension currently receiving 0 or 1 antihypertensive medication; mean sitting systolic blood pressure >/=140mmHg to </=170mmHg, or mean sitting diastolic blood pressure >/=90 to </=105mmHg. Subjects taking one hypertensive medication had their medication withdrawn and entered a wash-out phase prior to randomization.

You may not qualify if…

• Subject taking two or more antihypertensive medications, known contraindication to angiotensin-converting enzyme (ACE) inhibitors or alpha- or beta-blocker therapy, subject has Type 1 or Type 2 diabetes

Where it is running

• GSK Investigational Site — Chandler, Arizona, United States
• GSK Investigational Site — Glendale, Arizona, United States
• GSK Investigational Site — Goodyear, Arizona, United States
• GSK Investigational Site — Litchifield Park/Arizona, Arizona, United States
• GSK Investigational Site — Phoenix, Arizona, United States
• GSK Investigational Site — Tucson, Arizona, United States
• GSK Investigational Site — Anaheim, California, United States
• GSK Investigational Site — Beuna Park, California, United States
• GSK Investigational Site — Fountain Valley, California, United States
• GSK Investigational Site — Poway, California, United States
• GSK Investigational Site — San Ramon, California, United States
• GSK Investigational Site — Tustin, California, United States
• GSK Investigational Site — Vista, California, United States
• GSK Investigational Site — Coral Gables, Florida, United States
• GSK Investigational Site — DeLand, Florida, United States
• GSK Investigational Site — Fort Lauderdale, Florida, United States
• GSK Investigational Site — Hollywood, Florida, United States
• GSK Investigational Site — Miami, Florida, United States
• GSK Investigational Site — Pembroke Pines, Florida, United States
• GSK Investigational Site — Tamarac, Florida, United States
• GSK Investigational Site — West Palm Beach, Florida, United States
• GSK Investigational Site — Atlanta, Georgia, United States
• GSK Investigational Site — Savannah, Georgia, United States
• GSK Investigational Site — Nampa, Idaho, United States
• GSK Investigational Site — Mobile, Alabama, United States

Full record on ClinicalTrials.gov

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