Colonoscopic Removal of Aberrant Crypt Foci: a Prospective, Randomized, Blinded Trial

Completed · Not applicable

Conditions studied: Colorectal Neoplasms

In brief

We hypothesized that aberrant crypt foci (ACF) are precursors of colon cancer; their prevention would correlate with cancer risk and their elimination would reduce that risk. In this study we wished to (1) establish the feasibility of stain-enhanced magnification colonoscopy, (2) determine whether colorectal cancer is asociated with increased numbers of ACF, and (3) investigate the natural history of ACF and the durability of their elimination.

Key facts

Study ID

NCT00623883

Run by

National Naval Medical Center

People needed

98

Starts

1999-01-01

Expected to finish

2007-06-01

Last updated by the study team

2008-02-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Dept.of Defense Healthcare Beneficiaries
• Age 18 or over, non-pregnant
• History of colorectal cancer or other indication for colonoscopic screening
• At least half of large intestine remaining
• No use of investigational or chemotherapeutic drugs within 6 mos. -

You may not qualify if…

• History suggesting familial colon cancer syndrome
• < 6 mos since colon resection or since treatment for colon cancer
• Anticipated colon surgery within one year of entry
• Inability to participate in scheduled followup at one year
• Medical or psychiatric condition which would make patient a poor candidate -

Where it is running

• National Naval Medical Center — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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