Open Label Safety & Pharmacodynamic Study 24Wk w/DIO-902 Combo w/Metformin & Atorvastatin in T2DM Patients

Stopped early · Phase 2/Phase 3

Conditions studied: Type 2 Diabetes

In brief

DiObex Inc. is developing an experimental drug (DIO-902) that is made up of part of the ketoconazole molecule for the treatment of elevated blood glucose associated with type 2 diabetes mellitus. Ketoconazole (Nizoral®) is a drug available by prescription for the treatment of fungal infections however DIO-902 is an investigational drug. DIO-902 may lower blood glucose by lowering levels of a naturally occurring hormone called cortisol. Elevated cortisol may contribute to the development of type 2 diabetes.

Key facts

Study ID

NCT00622089

Run by

DiObex

People needed

150

Starts

2008-01-01

Expected to finish

2008-12-01

Last updated by the study team

2008-05-28

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participated in DIO-502

You may not qualify if…

• Did not participate in DIO-502

Where it is running

• Dr. Terence Hart — Muscle Shoals, Alabama, United States
• Genova Research — Tucson, Arizona, United States
• Research Solutions — Jonesboro, Arkansas, United States
• Arkansas Primary Care Clinic — Little Rock, Arkansas, United States
• Advanced Medical Research — Lakewood, California, United States
• Mills-Peninsula Helath Services — San Mateo, California, United States
• Diabetes Research Goup University of Hawaii at Manoa — Honolulu, Hawaii, United States
• Creighton Diabetes Center — Omaha, Nebraska, United States
• AHS Oklahoma Physician Group — Tulsa, Oklahoma, United States
• Covance Clinical Research Unit - Dr. Andrew Ahmann — Portland, Oregon, United States
• Covance CRU — Austin, Texas, United States
• Diabetes Glandular Disease Research Associates — San Antonio, Texas, United States
• Flinders Medical Centre — Adelaide, South Australia, Australia
• Lyell McEwin Hospital — North Western Adelaide, South Australia, Australia
• ECRU — Box Hill, Melbourne, Victoria, Australia
• School of Medicine and Pharmacology — Fremantle, Western Australia, Australia
• Keough Institute — Nedands, Western Australia, Australia
• Endocrinology Research Unit — Herston Road, Australia
• Endocrinology Department — St Leonards, Australia
• Royal Melbourn Hospital — Victoria, Australia
• Middlemore Hospital — Otahuhu, Auckland, New Zealand
• Lipid and Diabetes Research — Christchurch, New Zealand
• Waikaito Hospital — Hamilton, New Zealand
• Diabetes Centre — Wellington, New Zealand

Full record on ClinicalTrials.gov

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