AV Fistula Salvage in Advanced CKD Using Sodium Bicarbonate Prophylaxis
Withdrawn before enrolling
Conditions studied: Acute Renal Failure
In brief
This is an observational study assessing the impact of conventional dose iodinated contrast on the renal function of advanced chronic kidney disease patients undergoing arteriovenous fistula evaluation using a standard sodium bicarbonate prophylaxis protocol. In addition, this model allows for pre and post procedure measurements of kidney function, providing a unique opportunity to assess the utility of novel biomarkers for contrast-induced kidney injury. Our primary hypothesis is that there will be no change in serum creatinine post-procedure when using a standard sodium bicarbonate prophylaxis protocol. Our secondary hypothesis is that there will be no change in urinary kidney-injury marker-1 (KIM-1) post-procedure using a standard sodium bicarbonate prophylaxis protocol. In addition, we will assess the impact of different patient characteristics on the development of contrast-induced kidney injury, such as diabetes, coronary artery disease, hypertension, and angiotensin converting enzyme inhibitor therapy.
Key facts
- Study ID
- NCT00621972
- Run by
- MaineHealth
- People needed
- 0
- Starts
- 2008-01-01
- Expected to finish
- 2009-11-01
- Last updated by the study team
- 2018-09-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- English speaking
- >18 yrs age
- chronic kidney disease, documented GFR<30ml/min by abbreviated MDRD calculation
You may not qualify if…
- Inpatients
- Pediatric patients
- Non-English speaking patients
- established dialysis patients
- patients receiving iodinated contrast within 30 days of current procedure
- patients with central arterial manipulation within 30 days of current procedure
Where it is running
- Maine Medical Center - Brighton Campus — Portland, Maine, United States
Full record on ClinicalTrials.gov
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