Bevacizumab and Sorafenib in Treating Patients With Recurrent Glioblastoma Multiforme
Completed · Phase 2
Conditions studied: Brain and Central Nervous System Tumors
In brief
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Bevacizumab and sorafenib may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving bevacizumab together with sorafenib may kill more tumor cells. PURPOSE: This phase II trial is studying the side effects and how well giving bevacizumab together with sorafenib works in treating patients with recurrent glioblastoma multiforme.
Key facts
- Study ID
- NCT00621686
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 54
- Starts
- 2008-09-01
- Expected to finish
- 2014-02-19
- Last updated by the study team
- 2018-05-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Cancer Care Associates — Fresno, California, United States
- Front Range Cancer Specialists — Fort Collins, Colorado, United States
- Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center — Hartford, Connecticut, United States
- Baptist Cancer Institute - Jacksonville — Jacksonville, Florida, United States
- Mayo Clinic - Jacksonville — Jacksonville, Florida, United States
- Rush-Copley Cancer Care Center — Aurora, Illinois, United States
- Carle Cancer Center at Carle Foundation Hospital — Urbana, Illinois, United States
- CCOP - Carle Cancer Center — Urbana, Illinois, United States
- St. Francis Hospital and Health Centers - Beech Grove Campus — Beech Grove, Indiana, United States
- Reid Hospital & Health Care Services — Richmond, Indiana, United States
- McFarland Clinic, PC — Ames, Iowa, United States
- Cedar Rapids Oncology Associates — Cedar Rapids, Iowa, United States
- Mercy Regional Cancer Center at Mercy Medical Center — Cedar Rapids, Iowa, United States
- Medical Oncology and Hematology Associates - West Des Moines — Clive, Iowa, United States
- Mercy Capitol Hospital — Des Moines, Iowa, United States
- CCOP - Iowa Oncology Research Association — Des Moines, Iowa, United States
- John Stoddard Cancer Center at Iowa Methodist Medical Center — Des Moines, Iowa, United States
- Medical Oncology and Hematology Associates at John Stoddard Cancer Center — Des Moines, Iowa, United States
- Medical Oncology and Hematology Associates at Mercy Cancer Center — Des Moines, Iowa, United States
- Mercy Cancer Center at Mercy Medical Center - Des Moines — Des Moines, Iowa, United States
- John Stoddard Cancer Center at Iowa Lutheran Hospital — Des Moines, Iowa, United States
- McCreery Cancer Center at Ottumwa Regional — Ottumwa, Iowa, United States
- Siouxland Hematology-Oncology Associates, LLP — Sioux City, Iowa, United States
- Mercy Medical Center - Sioux City — Sioux City, Iowa, United States
- Mayo Clinic Scottsdale — Scottsdale, Arizona, United States
Full record on ClinicalTrials.gov
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