T-Wave Alternans in Dialysis Patients
Completed
Conditions studied: Sudden Cardiac Death, End Stage Renal Disease
In brief
Sudden cardiac death due to arrhythmia is the leading cause of death in end-stage renal disease (ESRD) patients treated with hemodialysis (HD). As it is anticipated that the number of individuals with ESRD will exceed 1.2 million in the next 20 years, sudden death in this population has enormous public health impact. Research has shown that arrhythmic events are temporally associated with longer periods between HD with a three-fold risk of events in the 12 hours preceding the longest inter-dialysis interval. The exact cause of these findings is unknown.
Key facts
- Study ID
- NCT00621426
- Run by
- Northwestern University
- People needed
- 40
- Starts
- 2007-04-01
- Expected to finish
- 2008-05-01
- Last updated by the study team
- 2015-03-12
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with chronic ESRD who have been on HD for at least 3 months
- Subjects 18 to 90 years of age with one or more risk factors for coronary artery disease or sudden cardiac death, including diabetes, peripheral vascular disease, known coronary artery disease, or ejection fraction < 40% by any imaging modality.
You may not qualify if…
- Subjects unwilling or unable to give written informed consent.
- Patients unable to return for regularly scheduled dialysis treatments
- Atrial fibrillation or flutter at screening
- Major surgical procedure two months prior to enrollment
- High grade heart block or a permanent pacemaker in situ
- Patients with known allergies to adhesive tape
Where it is running
- Northwestern University — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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