Vitamin D Levels in Children With IBD
Stopped early · Not applicable
Conditions studied: Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
In brief
Research has shown that children with Inflammatory Bowel Disease may have lower levels of vitamin D than healthy children, especially in the winter. Vitamin D is important for growing and maintaining healthy bones throughout life, and this is particularly important, since children with IBD frequently have low bone density. It may also be helpful in the treatment of IBD itself, because it helps reduce inflammation. Vitamin D levels are measured by the amount of 25 OHD in the blood; however, measuring this level on a regular basis is not yet the standard for children with IBD. The purpose of this study is to find the best way to treat low vitamin D levels, and to maintain good vitamin D levels throughout the year. It will also test whether having higher vitamin D levels will improve the bone health of children with IBD, and whether it will help them have milder disease.
Key facts
- Study ID
- NCT00621257
- Run by
- Boston Children's Hospital
- People needed
- 134
- Starts
- 2008-01-01
- Expected to finish
- 2011-03-01
- Last updated by the study team
- 2017-03-22
Who can join
Age: 5 and older, up to 21. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Clinical diagnosis of inflammatory bowel disease
- serum 25OHD level ≤ 20 ng/mL (Treatment Trial)
- serum 25OHD level > 20 ng/mL (Maintenance Trial)
You may not qualify if…
- Patients unable to take medications by mouth, pregnant, with liver/kidney failure, receiving anticonvulsant medications (specifically, phenobarbital, carbamazepine and phenytoin, since they lead to increased vitamin D metabolism through hepatic induction of the cytochrome P450 (CYP450) hydroxylase enzymes), regularly attending a tanning salon (once weekly or more), currently being treated for hypovitaminosis D with therapeutic doses of vitamin D (> 800 IU per day) and unwilling to discontinue this regimen.
- patients on growth hormone, anabolic steroid hormones, calcitonin, bisphosphonates (Maintenance Trial only)
Where it is running
- Children's Hospital, Boston — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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