Efficacy and Safety of Celecoxib Versus Ibuprofen in the Treatment of Osteoarthritis of the Knee (United States)

Completed · Phase 4 · Has a placebo group

Conditions studied: Osteoarthritis, Knee

In brief

To compare the efficacy and safety of celecoxib versus ibuprofen in subjects with osteoarthritis (OA) of the knee.

Key facts

Study ID

NCT00620867

Run by

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

People needed

393

Starts

2002-10-01

Expected to finish

2003-03-01

Last updated by the study team

2021-02-21

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged >= 40 years old
• Diagnosed with OA of the knee according to the American College of Rheumatology and OA in flare state at baseline visit
• Functional capacity class of I-III

You may not qualify if…

• Inflammatory arthritis or gout or pseudo-gout with acute flare within the past 2 years (subjects with fibrositis or fibromyalgia will not be excluded)
• Acute joint trauma at index joint within the past 3 months with active symptoms
• Score of >=20 on PHQ-9 or score of >=1 on PHQ-9 item i
• Use of mobility assisting device for <6 weeks or use of walker

Where it is running

• Pfizer Investigational Site — Anniston, Alabama, United States
• Pfizer Investigational Site — Phoenix, Arizona, United States
• Pfizer Investigational Site — Anaheim, California, United States
• Pfizer Investigational Site — Long Beach, California, United States
• Pfizer Investigational Site — Paramount, California, United States
• Pfizer Investigational Site — San Diego, California, United States
• Pfizer Investigational Site — DeLand, Florida, United States
• Pfizer Investigational Site — Miami, Florida, United States
• Pfizer Investigational Site — Naples, Florida, United States
• Pfizer Investigational Site — Pembroke Pines, Florida, United States
• Pfizer Investigational Site — St. Petersburg, Florida, United States
• Pfizer Investigational Site — Chicago, Illinois, United States
• Pfizer Investigational Site — Evansville, Indiana, United States
• Pfizer Investigational Site — Las Vegas, Nevada, United States
• Pfizer Investigational Site — Edison, New Jersey, United States
• Pfizer Investigational Site — South Plainfield, New Jersey, United States
• Pfizer Investigational Site — Albuquerque, New Mexico, United States
• Pfizer Investigational Site — Brooklyn, New York, United States
• Pfizer Investigational Site — New York, New York, United States
• Pfizer Investigational Site — Cincinnati, Ohio, United States
• Pfizer Investigational Site — Columbus, Ohio, United States
• Pfizer Investigational Site — Tulsa, Oklahoma, United States
• Pfizer Investigational Site — Altoona, Pennsylvania, United States
• Pfizer Investigational Site — Jenkintown, Pennsylvania, United States
• Pfizer Investigational Site — Newtown, Pennsylvania, United States

Full record on ClinicalTrials.gov

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