Proximal Molecular Effects of Concurrent Chemoradiotherapy on Head and Neck Squamous Cell Carcinoma

Completed

Conditions studied: Head and Neck Squamous Cell Carcinoma

In brief

This pilot study seeks to evaluate the feasibility of measuring the proximal effects of concurrent chemoradiotherapy (CRT) on the expression of potential therapeutic target molecules in Head and Neck Squamous Cell Carcinoma (HNSCC). Specifically, this study proposes to evaluate the extent to which CRT induces the differential expression of components along two critical, and potentially interdependent, molecular pathways: the arachidonic acid and epidermal growth factor receptor (EGFR) signaling pathways.

Key facts

Study ID

NCT00620139

Run by

Memorial Sloan Kettering Cancer Center

People needed

17

Starts

2005-03-01

Expected to finish

2013-10-01

Last updated by the study team

2013-10-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Untreated HNSCC (> Stage I) amenable to transoral biopsy.
• Scheduled for concurrent CRT (Cisplatin or Carboplatin/5-FU based) as definitive primary treatment
• Older than 18 years of age.
• Understand and sign informed consent.

You may not qualify if…

• Any prior treatment of the index cancer (chemotherapy, immunotherapy, hormonal therapy or radiation therapy) or similar treatment of an unrelated malignancy within 6 weeks of enrollment into this study.
• Breast-feeding, pregnancy or of childbearing potential (including those women who are less than two years post menopausal) and unable to confirm adequate contraception (abstinence, IUD, birth control pills, or spermicidal gel with diaphragm or condom) since last menses.
• History of chronic inflammatory disease (e.g. ulcerative colitis, Crohn's disease, rheumatoid arthritis or pancreatitis).
• Corticosteroid use within 6 weeks of enrollment, excluding topical nasal sprays.
• NSAID (including celecoxib) or aspirin (> 81 mg/day) use within 1 week of enrollment.
• Investigational medication use within 6 weeks of enrollment or is scheduled to receive an investigational drug during the course of the study.

Where it is running

• Memorial Sloan Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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