A Study of Decitabine Given Subcutaneously to Adults With Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS)
Completed · Phase 2
Conditions studied: Myelodysplastic Syndrome
In brief
The purpose of this study is to determine the effectiveness and safety of two different dose schedules of DACOGEN® (decitabine) for Injection in patients with Myelodysplastic Syndromes (MDS).
Key facts
- Study ID
- NCT00619099
- Run by
- Eisai Inc.
- People needed
- 67
- Starts
- 2008-05-01
- Last updated by the study team
- 2013-10-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Each patient must meet the following criteria to be enrolled in this study:
- Male or female patients age 18 years and older.
- Patients must sign an institutional review board (IRB)-approved informed consent form, and understand the investigational nature of this study and its potential hazards prior to initiation of any study-specific procedures or treatment.
- Must have Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
- Adequate renal and hepatic function (creatinine < 2 times upper limit of normal, total bilirubin of < 2 times upper limit of normal, and AST and ALT ≤ 2 times upper limit of normal) unless proven to be related to disease infiltration.
- Female patients need a negative serum or urine pregnancy test within 7 days prior to study drug administration (applies only if patient is of childbearing potential. Non-childbearing is defined as ≥ 1 year postmenopausal or surgically sterilized).
- Women of childbearing potential and men must use contraception. Men and women must continue birth control for the duration of the study.
- Patients with Low or Intermediate-1 Risk MDS by the International Prognostic Scoring System (IPSS) classification.
You may not qualify if…
- Patients who meet any of the following criteria will be excluded from the study:
- Women who are pregnant or nursing.
- Those who have received prior therapy with decitabine.
- Prior therapy with azacitidine (Vidaza®).
- Those who received growth factor support or lenalidomide in the 30 days prior to the first dose of decitabine.
- Those who have received an investigational agent 30 days prior to the first dose of decitabine.
- Patients with active, uncontrolled, systemic infection considered opportunistic, life threatening or clinically significant; or any severe, concurrent disease, which, in the judgment of the Investigator and after discussion with the Sponsor and Primary Investigator, would make the patient inappropriate for study entry.
Where it is running
- Gabrail Cancer Center — Canton, Ohio, United States
- Landmark Medical Center — Woonsocket, Rhode Island, United States
- Sarah Cannon Research — Nashville, Tennessee, United States
- M. D. Anderson — Houston, Texas, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.