Study to Evaluate the Effects of Weight Loss on Airway Inflammation and Mechanics in Subjects With Asthma (Asthma-Bariatric Surgery Study)
Completed
Conditions studied: Asthma
In brief
Current research shows that obesity greatly increases the risk of developing asthma. Although the two conditions are clearly related, experts do not fully understand why they are linked. Some researchers believe that hormones released in the fat cells (adipokines) play a role. Others believe that excess weight pressing on the lungs triggers the hyperreactive response in the airways that is typical of asthma. The goal of the Asthma-Bariatric Surgery Study is to determine how weight loss affects lung function and various biological parameters. Bariatric (weight loss) surgery refers to the various surgical procedures performed to treat obesity. Specifically, this study is designed to answer the following questions: * Does bariatric surgery help patients control their asthma? * How much asthma control can be achieved through weight loss? * How does weight loss influence lung function? Participants in this observational research study will be asked to complete study visits at enrollment, 1 month, 6 months, and 12 months. Questionnaires, pulmonary function tests, and blood samples will be required at each time point. This research study is observational only; it does not cover the cost of (or provide) bariatric surgery. Optional genetic and bronchoscopy substudies are included as well.
Key facts
- Study ID
- NCT00615498
- Run by
- Emory University
- People needed
- 80
- Starts
- 2006-07-01
- Expected to finish
- 2008-09-01
- Last updated by the study team
- 2013-07-31
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Non-smoker, or a limited smoking history
- Meet criteria for bariatric surgery according to NIH guidelines
You may not qualify if…
- Illicit drug use
- Greater than 10 pack-year history of cigarette smoking
- Other significant lung pathology
- Other significant non-pulmonary co-morbidities
Where it is running
- Emory University, Emory Crawford Long Hospital, Clinical Research Center — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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