Intravenous Versus Inhalational Anesthesia in Parkinson's Disease
Stopped early · Not applicable
Conditions studied: Parkinson's Disease
In brief
Parkinson's disease is a common progressive degenerative disease affecting 3% of all patients over the age of 65. Given their age and frailty, these patients frequently require surgical procedures with general anesthesia. However, after surgery, patients with Parkinson's disease have longer hospital stays and a greater chance of not returning to independent living compared to age-matched controls (Berman MF, unpublished data). In part, this is due to a higher rate of post-operative delirium, which had an incidence of 60% in this population in one study. There is anecdotal evidence from neurologists specializing in movement disorder suggesting that there is also significant deterioration in parkinsonian motor symptoms and cognition lasting for months or years following surgery and anesthesia. The basis for this deterioration is unknown. We hypothesize that these problems are caused by particular medications used during inhaled anesthesia for surgical procedures.
Key facts
- Study ID
- NCT00615472
- Run by
- Columbia University
- People needed
- 58
- Starts
- 2003-10-01
- Expected to finish
- 2011-04-01
- Last updated by the study team
- 2015-07-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Clinical diagnosis of Parkinson's Disease with bilateral deep brain stimulation surgery indicated as treatment
You may not qualify if…
- Not fluent in English
Where it is running
- Columbia Unviversity, Deparment of Anesthesiology — New York, New York, United States
Full record on ClinicalTrials.gov
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