Genetics of Peripheral Artery Genomics

Completed

Conditions studied: Peripheral Artery Disease

In brief

Peripheral artery disease is a disease that contributes to significant morbidity and mortality of millions of Americans yearly. Very little is known about the pathophysiology of atherosclerosis in peripheral artery disease. We plan to collect peripheral arteries and muscle tissue from patients undergoing amputation for end stage peripheral arterial occlusive disease. By extracting the RNA from these arteries and tissues and comparing them with RNA expression from normal arteries, we hope to have a better understanding of the pathophysiology of atherosclerosis in this setting. We aim to prove the hypothesis that a novel gene expression pattern can be discovered by the successful extraction of RNA from plaques from human peripheral arteries.

Key facts

Study ID

NCT00615121

Run by

Duke University

People needed

122

Starts

2004-06-01

Expected to finish

2016-01-01

Last updated by the study team

2016-01-25

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients undergoing amputations for peripheral artery disease
• Patients undergoing free fibular transfer

You may not qualify if…

• those that are not able to consent to the study

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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