A Study Combining FOLFOX or FOLFIRI With AG-013736 or Bevacizumab (Avastin) in Patients With Metastatic Colorectal Cancer After Failure Of One First Line Regimen

Completed · Phase 2

Conditions studied: Colorectal Neoplasms

In brief

The study is designed to demonstrate that the combination of AG-013736 with either FOLFIRI or FOLFOX is superior to FOLFIRI or FOLFOX in combination with bevacizumab (Avastin) in delaying tumor progression in the second-line treatment of patients with metastatic colorectal cancer after failure of an irinotecan or oxaliplatin-containing first-line regimen.

Key facts

Study ID

NCT00615056

Run by

Pfizer

People needed

171

Starts

2008-03-01

Expected to finish

2012-04-01

Last updated by the study team

2013-04-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically documented colorectal cancer plus one of the following:
• Failure of one prior irinotecan- or oxaliplatin-containing regimen, or
• Adjuvant refractory to irinotecan- or oxaliplatin-containing regimen.

You may not qualify if…

• Prior treatment in first line metastatic setting with more than one regimen
• Prior irradiation of more than 25% of bone marrow.

Where it is running

• Pfizer Investigational Site — Antioch, California, United States
• Pfizer Investigational Site — Los Angeles, California, United States
• Pfizer Investigational Site — Los Angeles, California, United States
• Pfizer Investigational Site — Pleasant Hill, California, United States
• Pfizer Investigational Site — San Leandro, California, United States
• Pfizer Investigational Site — Santa Monica, California, United States
• Pfizer Investigational Site — Aurora, Colorado, United States
• Pfizer Investigational Site — Bonita Springs, Florida, United States
• Pfizer Investigational Site — Bradenton, Florida, United States
• Pfizer Investigational Site — Cape Coral, Florida, United States
• Pfizer Investigational Site — Cape Coral, Florida, United States
• Pfizer Investigational Site — Englewood, Florida, United States
• Pfizer Investigational Site — Fort Myers, Florida, United States
• Pfizer Investigational Site — Fort Myers, Florida, United States
• Pfizer Investigational Site — Fort Myers, Florida, United States
• Pfizer Investigational Site — Fort Myers, Florida, United States
• Pfizer Investigational Site — Naples, Florida, United States
• Pfizer Investigational Site — Naples, Florida, United States
• Pfizer Investigational Site — Port Charlotte, Florida, United States
• Pfizer Investigational Site — Sarasota, Florida, United States
• Pfizer Investigational Site — Sarasota, Florida, United States
• Pfizer Investigational Site — Venice, Florida, United States
• Pfizer Investigational Site — Venice, Florida, United States
• Pfizer Investigational Site — Atlanta, Georgia, United States
• Pfizer Investigational Site — Mobile, Alabama, United States

Full record on ClinicalTrials.gov

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