Treatment Effect of Saxagliptin Compared With Placebo in Patients With Type 2 Diabetes and Renal Impairment

Completed · Phase 3 · Has a placebo group

Conditions studied: Type 2 Diabetes

In brief

Saxagliptin is a new investigational medication being developed for treatment of type 2 diabetes. This study is designed to test the efficacy of once daily saxagliptin in renally impaired patients.

Key facts

Study ID

NCT00614939

Run by

AstraZeneca

People needed

572

Starts

2008-01-01

Expected to finish

2010-03-01

Last updated by the study team

2011-05-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with type 2 diabetes
• Documented history of CrCl <50 ml/min within the 3 months prior to enrollment
• HbA1c ≥7.0% and ≤11.0%

You may not qualify if…

• Type 1 diabetes, history of diabetic ketoacidosis or hyposmolar non-ketonic coma
• Previous or current treatment with any DPP-IV inhibitor and/or GLP-1 mimetic.

Where it is running

• Research Site — Sacramento, California, United States
• Research Site — Denver, Colorado, United States
• Research Site — Topeka, Kansas, United States
• Research Site — Baltimore, Maryland, United States
• Research Site — Great Falls, Montana, United States
• Research Site — Greenville, North Carolina, United States
• Research Site — Morehead City, North Carolina, United States
• Research Site — Cincinnati, Ohio, United States
• Research Site — Corpus Christi, Texas, United States
• Research Site — Charleston, West Virginia, United States
• Research Site — Brest, Belarus
• Research Site — Homyel, Belarus
• Research Site — Minsk, Belarus
• Research Site — Dimitrovgrad, Bulgaria
• Research Site — Sofia, Bulgaria
• Research Site — Veliko Tarnovo, Bulgaria
• Research Site — Rijeka, Croatia, Croatia
• Research Site — Karlovac, Croatia
• Research Site — Osijek, Croatia
• Research Site — Split, Croatia
• Research Site — Zagreb, Croatia
• Research Site — Moravský Krumlov, Czechia
• Research Site — Prague, Czechia
• Research Site — Teplice, Czechia
• Research Site — Concord, California, United States

Full record on ClinicalTrials.gov

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