The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle

Completed · Not applicable · Has a placebo group

Conditions studied: Ovulation (Follicular Rupture Yes/no), Menstrual Cycles (Total Length, Bleeding Days), Gonadotropin and Ovarian Hormone Levels (FSH, LH, E2, P)

In brief

The investigators propose to test the hypothesis that the use of a prostaglandin inhibitor will result in premature luteolysis (ovulation failure) in women.

Key facts

Study ID

NCT00614406

Run by

Oregon Health and Science University

People needed

11

Starts

2008-01-01

Expected to finish

2008-08-01

Last updated by the study team

2012-12-13

Who can join

Age: 18 and older, up to 35. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Age 18-35
• Normal menstrual periods (24-35 days)
• Good general health
• Willing to use a non-hormonal form of contraception for the entire study (Acceptable forms of contraception include condoms, spermicide, sexual contact with a sterilized partner, subject is surgically sterile, same-sex partner, Copper IUD and abstinence)
• Willing and able to return to clinic for bi-weekly blood tests

You may not qualify if…

• Pregnant or breast feeding
• Polycystic ovarian disease
• Gastrointestinal conditions (i.e.gastric ulcer)
• Currently using birth control
• Known allergy to aspirin, non-steroidal anti-inflammatory drugs (NSAIDS) or Sulfa-drugs
• Diabetes
• Cardiac disease or hypertension
• Moderate to severe heartburn (GERD)
• Obesity (BMI greater than 30)

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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