Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus

Stopped early · Not applicable

Conditions studied: Normal Pressure Hydrocephalus

In brief

The research project is designed to determine which combination of tests will enable physicians to predict whether a patient with symptoms of normal pressure hydrocephalus (NPH) will improve with a shunt.

Key facts

Study ID

NCT00613886

Run by

University of California, Irvine

People needed

24

Starts

2006-03-01

Expected to finish

2009-04-01

Last updated by the study team

2021-01-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Walking difficulties in both legs which has developed gradually, not explained by other conditions, either in combination with mental impairment and urinary incontinence
• Brain CT or MRI findings of enlarged ventricles compared to established standards (minimum Evans ratio of 0.30 as measured by reviewing films)
• Mental impairment must be mild to moderate, emerging with or after the walking difficulties
• Age > or = 18 years old
• MMSE (Mini-mental status exam): < or = 10
• Urinary incontinence

You may not qualify if…

• No or only minimal walking difficulties combined with severe dementia
• Severe medical problems with limited life expectancy (less than six months)
• Contraindications to surgery
• Lack of informed consent

Where it is running

• University of California, Irvine - Medical Center — Orange, California, United States

Full record on ClinicalTrials.gov

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