Lactobacillus GG in the Prophylaxis of Ventilator Associated Pneumonia
Completed · Phase 3 · Has a placebo group
Conditions studied: Pneumonia, Ventilator Associated Pneumonia
In brief
This study utilizes lactobacillus, or probiotics, delivered twice daily to the mouth and stomach, via feeding tube, in effort to determine whether the oral administration of a naturally occurring Lactobacillus species reduces the incidence of ventilator associated pneumonia therefore reducing intensive care unit(ICU)complications.
Key facts
- Study ID
- NCT00613795
- Run by
- Creighton University
- People needed
- 125
- Starts
- 2004-08-01
- Expected to finish
- 2009-11-01
- Last updated by the study team
- 2010-03-18
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Admission to the medical, surgical, or cardiac ICU
- Age 19 years or greater (the age of majority in the state of Nebraska)
- Anticipated need for >72 hours of endotracheal intubation
- Initial intubation during hospitalization
- Approval of the attending physician responsible for the patient's care
- Informed surrogate consent within 24 hours of intubation
You may not qualify if…
- Pregnancy
- Pharmacologic immunosuppression (>10mg prednisone daily or equivalent for at least 14 days)
- Native immunosuppression: 1)known HIV disease or AIDS, 2)history of malignancy, 3)multiple organ system failure
- History of prosthetic or bioprosthetic cardiac valve placement
- History of prosthetic vascular graft placement
- Cardiac trauma
- History of rheumatic fever, endocarditis, congenital cardia abnormality, or acquired cardia abnormality
- Gastroesophageal surgery or perforation associated with current admission
- Intestinal surgery or perforation associated with current admission
- Significant oropharyngeal mucosal injury
- Placement of a tracheostomy
Where it is running
- Creighton University Medical Center — Omaha, Nebraska, United States
Full record on ClinicalTrials.gov
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