Early Diagnosis and Stem Cell Transplantation for Severe Immunodeficiency Diseases

Status unconfirmed · Phase 2

Conditions studied: Severe Immunodeficiency Diseases

In brief

The hypothesis of this study is that children with severe primary immunodeficiencies will benefit from early stem cell transplantation utilizing a reduced intensity conditioning regimen. This regimen is associated with a low risk of complications and will lead to correction of the underlying immunological defects.

Key facts

Study ID

NCT00613561

Run by

Ann & Robert H Lurie Children's Hospital of Chicago

People needed

25

Starts

2007-12-01

Expected to finish

2017-12-01

Last updated by the study team

2009-05-27

Who can join

Age: any, up to 11. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must show one of the following diseases:
• SCIDS
• Hyper-IgM
• Wiskott-Aldrich Syndrome
• Chediak-Higashi and Griscelli Syndromes
• X-Linked Lymphoproliferative Diseases
• IPEX Syndrome
• NEMO Syndrome
• other severe immunodeficiency diseases not stated above at the discretion of the Principal Investigator
• Informed Consent
• Adequate Renal Function
• Adequate Liver Function
• Adequate Cardiac Function
• Adequate Pulmonary Function
• Adequate Performance Statue
• Adequate Venous Access

You may not qualify if…

• Patient/Family has not signed informed consent
• Patient does not have a clear diagnosis of a severe immunodeficiency disease
• A suitable donor for the patient cannot be found
• Patient is HIV positive
• Patient has active Hepatitis B
• Patient is pregnant
• Patient is considered unsuitable for transplant at the discretion of the Principal Investigators or the medical director

Where it is running

• Children's Memorial Hospital — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.