Using Differences in Peripheral Blood Leukocyte Gene Expression to Determine Cardiovascular Disease Risk

Completed

Conditions studied: Atherosclerosis, Cardiovascular Diseases

In brief

Cardiovascular disease (CVD), including heart disease, heart attack, high blood pressure, and stroke, is most commonly caused by atherosclerosis, or a hardening of the arteries. Traditional risk factors for CVD include age, high blood pressure, high cholesterol, diabetes, and smoking. Although these established risk factors can be helpful in determining people at risk for developing CVD, the addition of novel gene markers for subclinical, or suspected, atherosclerosis (SA) may enhance CVD risk prediction and understanding of disease mechanisms. This study will compare specific genes of white blood cells in people with significant SA versus people without SA to improve identification of those at risk for developing CVD and to better understand the biological basis of SA.

Key facts

Study ID

NCT00613158

Run by

National Heart, Lung, and Blood Institute (NHLBI)

People needed

120

Starts

2007-03-01

Expected to finish

2010-02-01

Last updated by the study team

2016-07-29

Who can join

Age: 20 and older, up to 85. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Female participant from the MESA study who has a low Framingham risk score and has either SA or no evidence of SA
• Healthy female below the age of 40 from Northwestern University.

You may not qualify if…

• Diabetes

Where it is running

• Northwestern University — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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