To Evaluate the Pharmacodynamics, Safety, and Pharmacokinetics of Pazopanib Drops in Adult Subjects With Neovascular AMD

Completed · Phase 2

Conditions studied: Macular Degeneration

In brief

This is a 28 day study to evaluate the pharmacodynamic effect of pazopanib eye drops on the central retinal thickness of AMD patients

Key facts

Study ID

NCT00612456

Run by

GlaxoSmithKline

People needed

70

Starts

2008-03-05

Expected to finish

2009-06-17

Last updated by the study team

2017-11-20

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age-related macular degeneration patients diagnosed with subfoveal choroidal neovascularization in the study eye, with all of the following characteristics required:
• central subfield thickness > 300 microns on investigator-determined OCT (inclusive of subretinal fluid)
• active subfoveal leakage as determined by investigator-determined fluorescein angiography
• minimally classic or occult with no classic CNV lesion
• lesion size no greater than 12 disc areas
• CNV > 50% of lesion area
• < 50% of lesion area with blood
• = 25% of lesion area with fibrosis
• Best-corrected ETDRS visual acuity in the study eye between 80 to 24 letters inclusive (approximately 20/25 and 20/320 or 4/5 to 4/63) at screening
• Female subjects must be of non-childbearing potential.

You may not qualify if…

• Additional eye disease in the study eye that could compromise best corrected visual acuity (i.e. glaucoma with documented visual field loss, clinically significant diabetic retinopathy, ischemic optic neuropathy, or retinitis pigmentosa).
• CNV in the study eye due to other causes unrelated to age-related macular degeneration.
• The presence of retinal angiomatous proliferation (RAP) in the study eye, as determined by the investigator (confirmation by indocyanine green angiography is not required).
• Geographic atrophy involving the center of the fovea in the study eye.
• Anterior segment and vitreous abnormalities in the study eye that would preclude adequate observation of the fundus for photographs, fluorescein angiography and OCT.
• Vitreous, subretinal or retinal hemorrhage in the study eye that is unrelated to AMD.
• More than one prior photodynamic therapy (PDT) treatment in the study eye.
• PDT treatment in the study eye < 12 weeks prior to dosing.
• Previous treatment in the study eye with ranibizumab (Lucentis) or bevacizumab (Avastin) without resolution of exudation (intraretinal and subretinal fluid as documented by OCT).
• Use of any treatment, either approved or experimental, for AMD in the study eye within 60 days of first dose of investigational product.
• Intraocular surgery in the study eye within 3 months of dosing.
• Aphakia or total absence of the posterior capsule (Yttrium aluminum garnet (YAG) capsulotomy permitted) in the study eye.
• History of vitrectomy in the study eye.
• Use of topical ocular medications in the study eye within 7 days of first dose of investigational product or expected use of topical ocular medications during the treatment period, with the exception of artificial tears (refer to Section 9.1)
• Active treatment in the fellow eye, with the exception of preservative-free artificial tears.
• Current use of medications known to be toxic to the retina, lens or optic nerve (e.g. desferoximine, chloroquine/hydrochloroquine, chlorpromazine, phenothiazines, tamoxifen, nicotinic acid, and ethambutol).
• Use of systemic steroids (>10 mg prednisone or equivalent/day) within 14 days of first dose.
• An unwillingness to refrain from wearing contact lenses starting from the screening visit, through the follow-up visit
• Medical history or condition:
• Uncontrolled Diabetes Mellitus, with hemoglobin A1c (HbA1c) > 10%.
• Myocardial infarction or stroke within 12 months of screening.
• Active bleeding disorder.
• Major surgery within 1 month of screening.
• Hepatic impairment.
• Uncontrolled hypertension

Where it is running

• GSK Investigational Site — Tucson, Arizona, United States
• GSK Investigational Site — Beverly Hills, California, United States
• GSK Investigational Site — Pasadena, California, United States
• GSK Investigational Site — Sacramento, California, United States
• GSK Investigational Site — Fort Lauderdale, Florida, United States
• GSK Investigational Site — Winter Haven, Florida, United States
• GSK Investigational Site — Indianapolis, Indiana, United States
• GSK Investigational Site — Boston, Massachusetts, United States
• GSK Investigational Site — Ann Arbor, Michigan, United States
• GSK Investigational Site — Grand Rapids, Michigan, United States
• GSK Investigational Site — Toms River, New Jersey, United States
• GSK Investigational Site — Winston-Salem, North Carolina, United States
• GSK Investigational Site — Pittsburgh, Pennsylvania, United States
• GSK Investigational Site — Austin, Texas, United States
• GSK Investigational Site — Houston, Texas, United States
• GSK Investigational Site — Salt Lake City, Utah, United States
• GSK Investigational Site — Sydney, New South Wales, Australia
• GSK Investigational Site — Sydney, New South Wales, Australia
• GSK Investigational Site — Melbourne, Victoria, Australia
• GSK Investigational Site — Perth, Western Australia, Australia
• GSK Investigational Site — Leuven, Belgium
• GSK Investigational Site — Trieste, Friuli Venezia Giulia, Italy
• GSK Investigational Site — Milan, Lombardy, Italy
• GSK Investigational Site — Milan, Lombardy, Italy
• GSK Investigational Site — Turin, Piedmont, Italy

Full record on ClinicalTrials.gov

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