Safety/Efficacy Study of Retigabine vs. Placebo in Post-Herpetic Neuralgia (PHN)

Completed · Phase 2 · Has a placebo group

Conditions studied: Postherpetic Neuralgia

In brief

The purpose of the study is to evaluate the efficacy of retigabine vs. placebo in reducing pain associated with post-herpetic neuralgia.

Key facts

Study ID

NCT00612105

Run by

Bausch Health Americas, Inc.

People needed

187

Starts

2007-10-01

Expected to finish

2009-12-01

Last updated by the study team

2018-05-08

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to provide informed consent
• Male or female subjects
• 18-85 years of age
• PHN for more than 6 months after the healing of herpes zoster skin rash
• Has a pain score at screening and randomization that qualifies

You may not qualify if…

• Other significant pain that may potentially confound PHN pain assessment
• Previous neurolytic or neurosurgical therapy for PHN
• Subject has evidence of a progressive central nervous system (CNS) disease (e.g. CNS lupus, tumors, multiple sclerosis, Alzheimer's), lesion, or encephalopathy
• Significant psychiatric or neuropsychiatric disorders including but not limited to severe depression, bipolar disorder or schizophrenia spectrum disorder, history of suicide attempt, or recent history of suicidal ideation
• Has clinically significant abnormalities on physical examination, vital signs, ECG, or laboratory tests at the screening visit

Where it is running

• Study site — Birmingham, Alabama, United States
• Study site — Mesa, Arizona, United States
• Study site — Tucson, Arizona, United States
• Study site — Little Rock, Arkansas, United States
• Study site — Garden Grove, California, United States
• Study site — La Jolla, California, United States
• Study site — San Diego, California, United States
• Study site — Westlake Village, California, United States
• Study site — Orlando, Florida, United States
• Study site — Sarasota, Florida, United States
• Study site — Tampa, Florida, United States
• Study site — West Palm Beach, Florida, United States
• Study site — Atlanta, Georgia, United States
• Study site — Atlanta, Georgia, United States
• Study site — Evansville, Indiana, United States
• Study site — Overland Park, Kansas, United States
• Study site — Lexington, Kentucky, United States
• Study site — Shreveport, Louisiana, United States
• Study site — Bay City, Michigan, United States
• Study site — Detroit, Michigan, United States
• Study site — Hattiesburg, Mississippi, United States
• Study site — St Louis, Missouri, United States
• Study site — St Louis, Missouri, United States
• Study site — Toms River, New Jersey, United States
• Study site — New York, New York, United States

Full record on ClinicalTrials.gov

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