N-acetylcysteine and NMDA Antagonist Interactions
Completed · Phase 1/Phase 2 · Has a placebo group
Conditions studied: Cognitive Dysfunction
In brief
This study tests the hypothesis that extrasynaptic mechanisms are critically linked with cognitive effects of NMDA antagonism as evidenced by event-related potentials (ERPs) in healthy humans.
Key facts
- Study ID
- NCT00611897
- Run by
- Yale University
- People needed
- 16
- Starts
- 2006-01-01
- Expected to finish
- 2011-02-01
- Last updated by the study team
- 2015-05-08
Who can join
Age: 21 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Ages of 21-45 years from all ethnic backgrounds.
- Male or female.
- Written informed consent.
You may not qualify if…
- DSM-IV diagnosis for a psychotic, depressive or anxiety disorder.
- A history of significant medical/neurological disease such as cardiac, thyroid, renal, hepatic abnormality, seizure disorder. Unstable medical condition based on EKG, vital signs, physical examination and laboratory work-up (CBC with differential, SMA-7, LFTs, TFTs, UA, Utox, Urine pregnancy test) .
- History of severe allergies or multiple adverse drug reactions.
- Any medication that in the opinion of the PI could interfere with either the safety of the study and/or the outcome measures.
- Any other conditions which in the opinion of the investigator would preclude participation in the study.
- History of major psychiatric disorder in first degree relatives.
- Current substance abuse/dependency determined by urine toxicology.
- Current treatment with medications with psychotropic effects.
- Treatment with benzodiazepines within one week prior to testing.
- Current pregnancy, unsatisfactory birth control method report for females.
- Education < 10th grade.
- IQ < 70, MR as determined by Wechsler Abbreviated Scale of Intelligence.
- Non-English speaking.
Where it is running
- VHA Connecticut — West Haven, Connecticut, United States
Full record on ClinicalTrials.gov
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