The Use of Propranolol to Block Memory Reconsolidation in PTSD

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Posttraumatic Stress Disorders

In brief

The purpose of this investigation is to see if propranolol will reduce the psychophysiological hyperactivation associated with memories of combat stress in Veterans with Posttraumatic Stress Disorder.

Key facts

Study ID

NCT00611871

Run by

Wayne State University

People needed

12

Starts

2007-09-01

Expected to finish

2015-09-01

Last updated by the study team

2016-11-01

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Participants will meet the clinical criteria of PTSD (DSM IVTR) secondary to combat exposure.

You may not qualify if…

• Current illicit substance use or alcohol consumption, as determined by urine toxicology and alcohol breath test.
• Any diagnosis of current comorbid psychotic disorders, bipolar disorder, or illicit substance or alcohol abuse or dependence.
• Any current prescription medication usage or supplement (dietary or herbal) usage that is contraindicated with propranolol.
• Active enrollment into any psychiatric or psychological treatment.
• Any condition that contraindicates the use of propranolol, such as:
• history of bronchial asthma.
• heart block.
• sinus bradycardia.
• congestive heart failure.
• insulin-dependent diabetes.
• initial systolic blood pressure < 100 mmHg.
• Hyperthyroidism.
• Thyroid disease.
• Renal or liver impairment.

Where it is running

• John D Dingell VA Hospital — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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