Genomics of Chronic Renal Allograft Rejection (The GoCAR Study)

Completed

Conditions studied: Kidney Transplantation

In brief

Doctors have had success preventing certain types of kidney transplant rejection by suppressing the immune system. However, an individual's genetic make-up and the strength of an immune response to a transplant may also determine whether a transplanted organ is rejected. The purpose of this study is to look at the genetic profile and immune response of people who have had kidney transplants and to correlate the findings with kidney transplant rejection episodes. Donor genetic profiles will also be studied and correlated with the recipient's information.

Key facts

Study ID

NCT00611702

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

588

Starts

2008-06-01

Expected to finish

2013-07-01

Last updated by the study team

2015-05-14

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Kidney transplant candidates from living or deceased donors
• Male or female, ages 18-75 years
• Subject must be able to understand and provide written informed consent
• Living Donors - Recipient also consents to participate in the study

You may not qualify if…

• Presence of Donor Specific Antibodies in living donor recipients prior to transplantation OR positive cross match according to site-specific technique in cadaveric donor recipients
• Recipients of multiple organ transplants, with the exception of kidney/pancreas transplants.
• Inability or unwillingness to comply with the study protocol.

Where it is running

• Northwestern Memorial Hospital — Chicago, Illinois, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Mt. Sinai School of Medicine — New York, New York, United States
• University of Wisconsin-Madison — Madison, Wisconsin, United States
• Westmead Hospital — Sydney, New South Wales, Australia

Full record on ClinicalTrials.gov

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