Ph I Oral Topotecan and Temozolomide for Patients With Malignant Gliomas

Completed · Phase 1

Conditions studied: Glioblastoma, Gliosarcoma, Anaplastic Astrocytoma

In brief

Objectives: * To determine the maximum tolerated dose of oral topotecan when administered with Temodar to patients with malignant glioma * To characterize any toxicity associated with the combination oral topotecan and Temodar. * To observe patients for clinical antitumor response when treated with oral topotecan and Temodar.

Key facts

Study ID

NCT00610571

Run by

Katy Peters

People needed

62

Starts

2004-04-01

Expected to finish

2012-04-01

Last updated by the study team

2013-10-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histology: GBM, AA or grade 3 or greater WHO astrocytic, oligodendroglial or mixed glial tumors which were initially diagnosed by histologic exam of biopsy/resection
• Age: > or equal to 18 years
• Performance Status: Karnofsky Performance Status > or equal to 60% at study entry.
• Renal Function: Serum creatinine < 1.5 mg/dl or creatinine clearance > 60 ml/dL.
• Hematologic Status: The following baseline studies will be required before entry: total granulocyte count > or equal to 1000/microliter; platelet count > 100,000/microliter
• Hepatic Function: Serum SGOT \& total bilirubin < or equal to 2.5 times ULN.
• Note: All lab parameters must have been obtained within 1 week of registration
• Consent: Signed informed consent, approved by IRB, will be obtained prior to initiating treatment
• Corticosteroids: For patients currently on corticosteroids, patients should be on stable dose for 1 week prior to study entry, if clinically possible.
• Prior Therapy: Interval of at least 2 weeks between prior surgical resection or prior radiotherapy (XRT) or 1 week from completion of chemotherapy and all toxicities are < or equal to grade 1 \& enrollment on this protocol unless there is unequivocal evidence of progressive disease.
• Patients with Reproductive Potential: Patients must agree to practice effective birth control measures while on study and for 2 months after completing therapy

You may not qualify if…

• Pregnant or breast feeding women or women or men with reproductive potential not practicing adequate contraception. This therapy may be associated with potential toxicity to the fetus or child that exceeds minimum risks necessary to meet health needs of mother
• Active infection requiring intravenous antibiotics
• Prior failure with either topotecan or temozolomide

Where it is running

• Duke University Health System — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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