Neocortical Epilepsies - Do They Progress?
Completed · Not applicable
Conditions studied: Epilepsy
In brief
This study will use MRI and PET scan to compare the brain imaging results between epilepsy patients and normal healthy controls, also to study changes in 3 years.
Key facts
- Study ID
- NCT00610558
- Run by
- University of California, Irvine
- People needed
- 60
- Starts
- 2003-07-01
- Expected to finish
- 2010-09-01
- Last updated by the study team
- 2019-11-20
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Ages 18-65, based on the usual ages of patients seen in the adult neurology services who are not likely to suffer from the exclusions (see below).
You may not qualify if…
- History of seizures, faints, or any unexplained blackouts.
- Use of neuroleptic medications or sedating doses of antianxiety or antidepressant drugs.
- They should not have a clear family history of epilepsy (first degree relatives).
- History of any substance abuse within the past 5 years.
- History of progressive medical or neurologic disease (Parkinson's, severe congestive heart failure). Controlled hypertension, diabetes (by oral medications or diet), asthma, etc will not be excluded.
- History of stroke without complete recovery of neurologic function.
- Pregnancy
- With any metallic implants, including surgical clips (hemostatic clips), pacemakers, neuro-stimulation devices, prosthetic heart valves, or other ferromagnetic material.
- Inability to understand the consent. (standard form attached)
- Inability to speak fluent English. Note: the neuropsychological tests are standardized for English speakers. They are not all available in multiple languages. Since the scoring and norms are established for English speakers, simply translating them would still not make the testing norms and scoring applicable.
- Juvenile Myoclonic Epilepsy (JME; 20 Subjects):
- Inclusion Criteria:
- Ages 18-65, based on the usual ages of patients seen in the adult neurology services who are not likely to suffer from the exclusions (see below), plus
- History of myoclonic plus tonic-clonic or clonic-tonic-clonic seizures with or without absence seizures.
- EEG consistent with primary generalized epilepsy (>/= 3 c/s generalized, frontal maximum, poly spike and wave; normal alpha)
- Exclusion Criteria
- History of significant head injury (> 30 min loss of consciousness)
- Use of neuroleptic drugs or sedative doses of antianxiety or antidepressant drugs
- History of any substance abuse within the past 5 years
- Presence of epileptogenic brain lesion on MRI (tumor, stroke, cortical congenital dysplasia, etc; excluding normal variants, mild subcortical white matter ischemic change, venous angiomas).
- EEG with focal epileptiform potentials or polymorphic slowing
- History of progressive medical or neurologic disease (Parkinson's, severe congestive heart failure). Controlled hypertension, diabetes (by oral medications or diet), asthma, etc will not be excluded.
- History of stroke without complete recovery of neurologic function.
- Pregnancy
- With any metallic implants, including surgical clips (hemostatic clips), pacemakers, neuro-stimulation devices, prosthetic heart valves, or other ferromagnetic material.
Where it is running
- Center for Functional Onco-Imaging, University of California — Irvine, California, United States
Full record on ClinicalTrials.gov
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