Tear Film Stability After Instillation of Over-the-Counter (OTC) Artificial Drops

Completed · Not applicable

Conditions studied: Dry Eye Disease

In brief

The goal of this research is to evaluate and compare the effectiveness of Systane® versus Optive™ on aqueous tear film stability in patients with a diagnosis of Dry Eye Syndrome and to determine the possible application for this product in the future. Systane® is marketed as over-the-counter tear lubricating therapy in the United States under the FDA monograph.

Key facts

Study ID

NCT00610480

Run by

University of Texas Southwestern Medical Center

People needed

20

Starts

2007-11-01

Expected to finish

2009-03-01

Last updated by the study team

2020-11-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Individuals aged 18 and up will be included, where any age over 89 will be recorded as 'greater than 89.'
• Individuals with bilateral eye sight eye correctable to 20/80 or better.
• Individuals in good health with or without Meibomian Gland Dystrophy (MGD) but with Aqueous Tear Deficiency (ATD) with minimal to no ocular surface inflammation on slit lamp examination.

You may not qualify if…

• Individuals with only one sighted eye or vision not correctable to 20/80 or better in both eyes.
• Individuals with history of punctal plugs or punctal occlusions.
• Individuals with history of keratorefractive as well as ophthalmic disease such as corneal dystrophies, glaucoma, or systemic disease affecting the eye (such as Herpes Zoster).
• Individuals with history of systemic or ocular auto-immune conditions.
• Individuals with active systemic disease or those taking systemic medication that are known to influence AT production will not be considered for this trial.
• Individuals using topical medication who are unable to discontinue them for at least 24 hours prior to baseline evaluation will be excluded as well.

Where it is running

• UTSW Medical Center at Dallas - Aston Ambulatory Care Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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