Randomized Study Of Sunitinib Plus FOLFOX Versus Bevacizumab Plus FOLFOX In Metastatic Colorectal Cancer

Stopped early · Phase 2

Conditions studied: Colorectal Neoplasms

In brief

This study will compare the safety and efficacy of sunitinib in combination with FOLFOX versus bevacizumab in combination with FOLFOX for the treatment of patients with metastatic colorectal cancer who have not been treated before.

Key facts

Study ID

NCT00609622

Run by

Pfizer

People needed

191

Starts

2008-04-01

Expected to finish

2011-07-01

Last updated by the study team

2012-10-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adenocarcinoma of the colon or rectum with locally advanced or metastatic disease
• Evidence of measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST)
• Eastern Cooperative Oncology Group (ECOG) 0 or 1

You may not qualify if…

• Previous treatment with Sutent, Avastin, or any other systemic therapy for locally advanced or metastatic colorectal cancer
• Less than 6 months since completion of adjuvant chemotherapy to documentation of recurrent disease
• History of cardiac disease
• Brain mets

Where it is running

• Pfizer Investigational Site — Mobile, Alabama, United States
• Pfizer Investigational Site — Chandler, Arizona, United States
• Pfizer Investigational Site — Mesa, Arizona, United States
• Pfizer Investigational Site — Bentonville, Arkansas, United States
• Pfizer Investigational Site — Fayetteville, Arkansas, United States
• Pfizer Investigational Site — Hot Springs, Arkansas, United States
• Pfizer Investigational Site — Bakersfield, California, United States
• Pfizer Investigational Site — Fresno, California, United States
• Pfizer Investigational Site — Fullerton, California, United States
• Pfizer Investigational Site — Lancaster, California, United States
• Pfizer Investigational Site — Los Angeles, California, United States
• Pfizer Investigational Site — Los Angeles, California, United States
• Pfizer Investigational Site — Los Angeles, California, United States
• Pfizer Investigational Site — Mission Hills, California, United States
• Pfizer Investigational Site — Northrige, California, United States
• Pfizer Investigational Site — Oxnard, California, United States
• Pfizer Investigational Site — Pasadena, California, United States
• Pfizer Investigational Site — Redondo Beach, California, United States
• Pfizer Investigational Site — Santa Barbara, California, United States
• Pfizer Investigational Site — Santa Maria, California, United States
• Pfizer Investigational Site — Santa Monica, California, United States
• Pfizer Investigational Site — Solvang, California, United States
• Pfizer Investigational Site — Valencia, California, United States
• Pfizer Investigational Site — Aurora, Colorado, United States
• Pfizer Investigational Site — Fairhope, Alabama, United States

Full record on ClinicalTrials.gov

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