Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)

Running, not enrolling

Conditions studied: Pulmonary Disease, Chronic Obstructive, Emphysema, Bronchitis, Chronic

In brief

Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused by cigarette smoking. The purpose of this study is to evaluate whether certain genetic factors predispose some smokers to develop COPD more than others.

Key facts

Study ID

NCT00608764

Run by

Brigham and Women's Hospital

People needed

10718

Starts

2007-11-01

Expected to finish

2028-08-01

Last updated by the study team

2025-09-17

Who can join

Age: 45 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• At least 10 pack-years of cigarette smoking (although a of nonsmoking controls is also being enrolled)
• Self-designation of non-Hispanic white or African-American

You may not qualify if…

• Other lung diseases (except for asthma in participants with COPD)
• Pregnant
• Cancer (other than skin cancer) in the 5 years prior to study entry
• Received antibiotics for a COPD exacerbation in the 1 month prior to study entry
• First- or second-degree relative of a previously enrolled study participant

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• University of California at San Diego — San Diego, California, United States
• Los Angeles Biomedical Research Institute — Torrance, California, United States
• National Jewish Health — Denver, Colorado, United States
• Morehouse School of Medicine — Atlanta, Georgia, United States
• University of Iowa — Iowa City, Iowa, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Reliant Medical Group — Worcester, Massachusetts, United States
• Ann Arbor VA Medical Center — Ann Arbor, Michigan, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Minneapolis VA Medical Center — Minneapolis, Minnesota, United States
• HealthPartners Research Foundation — Minneapolis, Minnesota, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Columbia University Medical Center — New York, New York, United States
• Duke University — Durham, North Carolina, United States
• Temple University — Philadelphia, Pennsylvania, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• Baylor College of Medicine — Houston, Texas, United States
• University of Texas Health Sciences Center at San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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