A Study To See If GSK256073A Can Block Niacin-Induced Flushing In Healthy Volunteers

Completed · Phase 1

Conditions studied: Healthy Subjects, Dyslipidaemias

In brief

To test the ability of GSK256073 to block niacin-induced flushing when GSK256073 and niacin are co-administered as single doses to HVTs.

Key facts

Study ID

NCT00608699

Run by

GlaxoSmithKline

People needed

24

Starts

2007-12-01

Expected to finish

2008-04-01

Last updated by the study team

2012-04-30

Who can join

Age: 18 and older, up to 55. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Adult males between 18 and 55 years of age, inclusive.
• Healthy subjects
• Body weight > 50 kg (110 pounds) and body mass index (BMI) between 19 and 31 where:
• Subjects with QTc < 450 msec at screening

You may not qualify if…

• History of significant cardiac arrhythmias
• Active peptic ulcer disease (PUD) and/or history of PUD
• History of gout and/or hyperuricemia
• History of Gilbert's syndrome
• History of recurrent indigestion, stomach upset or diarrhea
• History of other than rare (once yearly or less) flushing
• Recurrent skin rash or psoriasis
• History of kidney stones

Where it is running

• GSK Investigational Site — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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