Transcranial Magnetic Stimulation to Improve Speech in Aphasia
Completed · Phase 1 · Has a placebo group
Conditions studied: Aphasia, Cerebrovascular Stroke
In brief
The purpose of this study is to examine whether repetitive transcranial magnetic stimulation (rTMS) can be used to improve speech in chronic stroke patients with aphasia. Aphasia patients can have problems with speech production. The rTMS procedure allows painless, noninvasive stimulation of human cortex from outside the head. Chronic aphasia patients have been observed in our functional magnetic resonance brain imaging studies to have excess brain activation in brain areas possibly related to language on the right side of the brain (opposite side to where the stroke took place). It is expected that suppression of activity in the directly targeted brain region will have an overall modulating effect on the neural network for naming (and propositional speech) and will result in behavioral improvement.
Key facts
- Study ID
- NCT00608582
- Run by
- Boston University
- People needed
- 63
- Starts
- 2002-07-01
- Expected to finish
- 2013-06-01
- Last updated by the study team
- 2017-01-31
Who can join
Age: 45 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Right Handed
- Single, Left Hemisphere Cerebrovascular Stroke
- Must be at least 6 months poststroke onset
- Native Speaker of English
- Clinical Diagnosis of Aphasia
You may not qualify if…
- Intracranial metallic body from prior neurosurgical procedure
- Implanted metallic devices: pacemaker, medication pump, vagal stimulator, deep brain stimulator, TENS unit or ventriculoperitoneal shunt
- Past history of seizure within 1 year
- Pregnancy
- History of substance abuse within last 6 months
Where it is running
- VA Boston Healthcare System, Jamaica Plain Campus, Boston University Aphasia Research Center (12-A), 150 So. Huntington Ave. — Boston, Massachusetts, United States
- Berenson-Allen Center for Noninvasive Brain Stimulation, 330 Brookline Ave, Kirstein Bldg., Dept. of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School — Boston, Massachusetts, United States
- Department of Neurology, Hospital of the University of Pennsylvania, 3 W. Gates Bldg. — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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