A Study of Safety and Pharmacokinetics of Repeated Dose of Micafungin as Antifungal Prophylaxis in Children and Adolescents Who Undergo Hematopoietic Stem Cell Transplant

Completed · Phase 1

Conditions studied: Fungal Infections

In brief

The study will evaluate PK and safety of two dose levels of Micafungin (FK463) as Antifungal prophylaxis in children and adolescents undergoing HSCT

Key facts

Study ID

NCT00606268

Run by

Astellas Pharma Inc

People needed

42

Starts

2007-11-01

Expected to finish

2009-03-01

Last updated by the study team

2014-08-21

Who can join

Age: 0 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Institutional Review Board (IRB)-approved written informed Consent / Assent (as applicable) and HIPAA Authorization must be obtained from the subject (as able) and /or subject's parent/legally authorized representative prior to any study-related procedures
• Subject has sufficient venous access to permit administration of study drug, collect pharmacokinetic samples and monitor laboratory safety variables
• Female subject of childbearing potential must have a negative pregnancy test within 72 hours prior to the first dose of study drug, and if sexually active agree method of birth control per Investigator judgment for the duration of the study
• Subject (when able) and /or subjects parent/legally authorized representative agree to comply with the study requirements and with the concomitant medication restrictions
• Subject plans to undergo a HSCT

You may not qualify if…

• Subject has evidence of significant liver disease as defined by aspartate transamine (AST/SGOT), alanine transaminases (ALT/SGPT) 10 times the upper limit of normal (ULN) and total bilirubin or alkaline phosphatase > 5 times the ULN
• Subject has concomitant medical condition that in the opinion of the Investigator and /or medical monitor precludes enrollment into the study
• Subject with evidence of an active systemic or disseminated fungal infection prior to enrollment
• Subject has a history of anaphylaxis, hypersensitivity, or any serious reactions to the echinocandin class of antifungals
• Subject had received treatment with an echinocandin within one week prior to first dose of study drug
• Subject status is unstable and subject is unlikely to complete required study procedures
• Female subject is pregnant or nursing. Females of childbearing potential must avoid becoming pregnant while receiving study drug

Where it is running

• Study site — Los Angeles, California, United States
• Study site — Orange, California, United States
• Study site — Palo Alto, California, United States
• Study site — Denver, Colorado, United States
• Study site — Chicago, Illinois, United States
• Study site — Indianapolis, Indiana, United States
• Study site — Minneapolis, Minnesota, United States
• Study site — Rochester, New York, United States
• Study site — Philadelphia, Pennsylvania, United States
• Study site — Memphis, Tennessee, United States
• Study site — Houston, Texas, United States
• Study site — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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