Yoga for the Treatment of Metabolic Syndrome

Completed · Phase 1

Conditions studied: Metabolic Syndrome

In brief

We tested the following hypotheses: 1. That a standardized yoga therapy will improve insulin sensitivity (primary outcome), and other features of the metabolic syndrome such as hypertension and dyslipidemia (secondary outcomes), we will perform a 2-hour oral glucose tolerance test, fasting blood tests, and a physical examination before and after randomization of subjects to a 10-week yoga therapy intervention or wait-list control group. 2. That a yoga therapy is feasible in overweight and underactive individuals with the metabolic syndrome, that adherence to a yoga intervention is acceptable, and that yoga therapy is associated with improved quality of life, we will assess the adherence to twice-weekly yoga group sessions (for weeks1-5) and weekly yoga group sessions (for weeks 6-10), frequency of home yoga therapy practice, and self-reported quality of life before and after the intervention in both treatment groups. 3. To elucidate a potential mechanism for the effect of yoga on changes in insulin resistance by evaluating markers of inflammation from adipose tissue (adipocytokines). We hypothesize that these biochemical parameters will show modest improvement with yoga therapy and that changes in these parameters will be associated with improvements in insulin sensitivity.

Key facts

Study ID

NCT00605436

Run by

University of California, San Francisco

People needed

26

Starts

2006-10-01

Expected to finish

2007-06-01

Last updated by the study team

2008-01-31

Who can join

Age: 30 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• to be between the ages of 30 and 65 years,
• fulfill at least three criteria for the metabolic syndrome per the NCEP guidelines:
• waist circumference (>88 cm for women; >102 cm for men),
• HDL-cholesterol (<50 mg/dl for women; <40 mg/dl for men),
• triglycerides >=150 mg/dL
• fasting glucose >=100 mg/dL, and/or
• high blood pressure (>=130/>=85 or use of antihypertensive medication), and
• report an underactive or sedentary lifestyle defined as accumulating less than 30 minutes of moderate intensity endurance exercise 5 days per week.

You may not qualify if…

• Pregnancy or lactation
• Coronary heart disease (defined as a myocardial infarction or cardiac intervention with percutaneous transluminal catheterization or coronary artery bypass graft surgery) event or hospitalization in the past 6 months
• Chronic illnesses: cancer, kidney disease, cirrhosis, rheumatogic diseases, or chronic infections
• Current use of these medications: oral diabetes medications, insulin, steroid hormones, oral contraceptives, hormone replacement therapy, niacin, fibrates.
• Regular participation (>1/week) yoga for past 3 months or concurrent use of yoga
• Current major psychiatric illness, cognitive impairment, or substance abuse
• Plans to move out of the study region within 6 months
• Life-expectancy of < 6 months
• Concurrent enrollment in any other studies, experimental therapies, or blinded treatments

Where it is running

• University of California, San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

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